姓名王杰                  

研究方向分析化学、化学信息学以及生物化学

联系电话:027-87197359;18627952376

联系地址:湖北省武汉市小洪山西30号中国科学院武汉物理与数学研究所波谱楼,430071

E-mailjie.wang@wipm.ac.cn

 

 

 

学习经历: 

           9/2000 ~ 7/2004             兰州大学化学化工学院化学基地班                         学士学位

           9/2004~10/2009             兰州大学化学化工学院分析化学专业                     博士学位

           10/2007~10/2009           耶鲁大学生物医学工程专业                                   联合培养博士

             

工作经历

11/2005 ~ 09/2007         兰州大学出版社编辑

12/2009~09/2012          中国科学院武汉物理与数学研究所                            助理研究员

10/2010-03/2013           耶鲁大学医学院放射诊断系                                       博士后

10/2012-至今                中国科学院武汉物理与数学研究所                              副研究员

 

主要奖励:

            兰州大学奖学金(共10次);兰州大学优秀学生干部(2);兰州大学优秀学生会干部(1);海正奖学金(2);求是奖学金(1);兰州大学优秀班主任(2);甘肃省科技进步三等奖(1);兰州市科技进步二等奖(1)。

 

 

研究兴趣:

 主要从事有关分析化学、化学信息学、生物化学等相关领域的研究,现主要从事生物体代谢动力学研究、微透析以及核磁共振成像方面的研究。

 

发表论文:

1.      Jie Wang, Hongying Du, Xiaoxian Ma, Brian Pittman, Laura Castracane Ting-Kai Li, Kevin L. Behar, Graeme F. Mason, Metabolic Products of [2‐13C] Ethanol in the Rat Brain after Chronic Ethanol Exposure, Journal of Neurochemistry, 2013, In press.

2.      Jie Wang, Hongying Du, Lihong Jiang, Xiaoxian Ma, Robin A. de Graaf, Kevin L. Behar, and Graeme F. Mason, Oxidation of ethanol in the rat brain and effects associated with chronic ethanol exposure, Proceeding of the National Academy of Sciences of the United States of America, 2013, 110(35), 14444–14449.

3.      Jie Wang, Lihong Jiang, Hongying Du, Kevin L. Behar, Ting-Kai, Li, Graeme F. Mason, Ethanol as metabolic precursor and fuel for the brain, , Alcoholism: Clinical and Experimental Research, 2013, 37(s2), 254A.

4.      Jie Wang, Lihong Jiang, Hongying Du, Graeme F. Mason, An ethanol vapor chamber for small animals, Alcoholism: Clinical and Experimental Research, 2012, 36(s1), 29A.

5.      Jie Wang, Peter C. Nicholas, Daniel Kim, Xiaoxian Ma, Ting-Kai Li, Jeffrey M. Macdonald, Fulton T. Crews, Graeme Mason, Metabolic products of [1-13C] ethanol in the awake rat brain, Alcoholism: Clinical and Experimental Research, 2012, 36(s1), 83A.

6.      Jie Wang, Lihong Jiang, Hongying Du, Graeme F. Mason, An ethanol vapor chamber system for small animals, Journal of Neuroscience Methods, 2012, 208, 79-85.

7.      Jie Wang, Qing Liu, Lihong Jiang, Fuqiang Xu, NMR method for determining energy metabolism and neurotransmission kinetics in brain. Chinese Journal of Magnetic Resonance, 2010, 27(3), 341-354.

8.      Jie Wang, Lihong Jiang, Yifeng Jiang, Xiaoxian Ma, Golam M. I. Chowdhury, Graeme F. Mason, Regional metabolite levels and turnover in the awake rat brain under the influence of nicotine, Journal of Neurochemistry, 2010, 113, 1447-1458.

9.      Jie Wang, Hongying Du, Xiaojun Yao, Zhide Hu, Using Classification Structure Pharmacokinetic Relationship (CSPR) method to Predict Drug Bioavailability Based on Grid-Search Support Vector Machine, Analytica Chimica Acta, 2007, 601, 156-163.

10.  Jie Wang, Hongying Du, Huanxiang Liu, Xiaojun Yao, Zhide Hu, Prediction of Surface Tension for Common Compounds Based on Novel Methods Using Heuristic Method and Support Vector Machine, Talanta, 2007, 73, 147–156.

11.  Jie Wang, Huanxiang Liu, Shen Qin, Xiaojun Yao, Mancang Liu, Zhide Hu, Botao Fan,Study on the Structure-Activity Relationship of New Anti-HIV Nucleoside Derivatives Based on the Support Vector Machine Method, QSAR & Combinatorial Science, 2007, 26(2): 161-172.

12.  Jie Wang, Huanxiang Liu, Hongzong Si, Xiaojun Yao, Mancang Liu, Zhide Hu, Prediction of the Power Rotation of the Amino Acid Based on the Quantitative Structure-Property Relationship Method, Chinese Journal of Analytical Chemistry, 2006, 34 (12):1759-1762.

13.  Nan Wu, Xiaoping Rao, Yunling Gao, Jie Wang, Fuqiang Xu, Amyloid-β Deposition and Olfactory Dysfunction in an Alzheimer's Disease Model, 2013, Journal of Alzheimer's Disease, In press.

14.  Wojciech Solecki, Robert J. Wickham, Shay Behrensa, Jie Wang, Blake Zwerling, Graeme F. Mason, Nii A. Addy, Differential role of ventral tegmental area acetylcholine and N-methyl-d-aspartate receptors in cocaine-seeking, Neuropharmacology, 2013,75, 9–18.

15.  Wojciech Solecki, Robert Wickham, Blake Zwerling,Jie Wang, Graeme Mason, Nii A. Addy, Phasic dopamine release mediates cue-evoked cocaine-seeking during abstinence, Program No. 72.07/AA2, 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Online.

16.  Hongying Du, Jie Wang, June Watzl, Xiaoyun Zhang, Zhide Hu, Classification Structure Activity Relationship (CSAR) Studies for Prediction of Genotoxicity of Thiophene Derivatives, Toxicology Letters, 2008, 177, 10-19.

17.  Hongying Du, Jie Wang, Xiaoyun Zhang, Xiaojun Yao, Zhide Hu, Prediction of retention times of peptides in RPLC by using radial basis function neural networks and projection pursuit regression, Chemometrics and Intelligent Laboratory Systems, 2008, 92, 92-99.

18.  Hongying Du, Jie Wang, June Watzl, Xiaoyun Zhang, Zhide Hu, Quantitative Structure Activity Relationship (QSAR) Studies for Prediction of the Inhibition of Matrix Metalloproteinase Inhibitors Based on the Combination of Projection Pursuit Regression and Grid Search method, Chemometrics and Intelligent Laboratory Systems, 2008, 93,160-166.

19.  Hongying Du, Jie Wang, Zhide Hu, Xiaojun Yao, Quantitative Structure-Retention Relationship study of the constituents of saffron aroma in SPME-GC-MS based on the Projection Pursuit Regression method, Talanta, 2008, 77, 360-365. 

20.  Hongying Du, Jie Wang, Xiaoyun Zhang, Zhide Hu, A novel quantitative structure - activity relationship method to predict the affinities of MT3 melatonin binding site, European Journal of Medicinal Chemistry, 2008, 43(12), 2861-2869.

21.  Hongying Du,Jie Wang, Zhide Hu, Xiaojun Yao, Xiaoyun Zhang, Prediction of fungicidal activities of rice blast disease based on least squares support vector machines and project pursuit regression, Journal of Agricultural and Food Chemistry, 2008, 56 (22), 10785–10792.

22.  Hongying Du, Jie Wang, Xiaojun Yao, Zhide Hu, Quantitative structure-retention relationships models for the prediction of the reversed-phase HPLC gradient retention based on the Heuristic Method and Support Vector Machine, Journal of Chromatographic Science, 2009, 47, 396-404.

23.  Hongying Du, Jie Wang, Zhide Hu, Mancang Liu, Xiaojun Yao, Prediction of relative sensitivity of the olfactory and nasal trigeminal chemosensory systems for a series of the volatile organic compounds based on local lazy regression method, Sensors and Actuators B: Chemical, 2009, 138, 55-63.

24.  Hongying Du, Xiaoyun Zhang, Jie Wang, Xiaojun Yao, Zhide Hu, Novel approaches to predict the retention of histidine-containing peptides in immobilized metal-affinity chromatography, Proteomics, 2008, 11, 2185-2195.

25.  Hongying Du, June Watzl, Jie Wang, Xiaoyun Zhang, Xiaojun Yao, Zhide Hu, Prediction of retention indices of drugs based on immobilized artificial membrane chromatography by using projection pursuit regression and local lazy regression, Journal of Separation Science, 2008, 31, 2325-2333.

26.  Shen Qin, Huanxiang Liu, Jie Wang, Xiaojun Yao, Mancang Liu, Zhide Hu, Botao Fan, Quantitative Structure-Activity Relationship study on a series of novel ligands binding to central benzodiazepine receptor by using the combination of Heuristic Method and Support Vector Machines, QSAR & Combinatorial Science, 2007, 26(4), 443-451.